Among male infertility patients caused by spermatogenesis disorders, the incidence of Y chromosome microdeletions is second only to Klinefelter ’s syndrome (Klinefelter ’s syndrome) and is the second most important genetic factor. This kit is used for rapid detection of microdeletions of 15 sequence tags on the AZFa, AZFb and AZFc loci of the Y chromosome AZF (AzoospermiaFactor) gene family from male anticoagulated peripheral whole blood.
To provide a molecular basis for diagnosis of male infertility, to avoid unnecessary medication or surgical treatment;
To provide guidance for clinically assisted reproduction (e.g. injection in monosperm follicle);
Identify the Y chromosome AZF micromissarea to provide a basis for selecting the right clinical treatment.
The 2013 edition of the European Andrology Association (EAA) and the European Molecular Genetic Diagnostic Quality Alliance (EMQN) released guidelines for the detection of Y chromosome microdeletions, recommending the detection of 6 STS sites.
Premarital examination and risk assessment
Screening of causes of infertility patients
Detection of specimens: Anticoagulant whole blood or genomic DNA
Technical principle:Multiplex-PCR
Packing size:25tests / kit
Category: In vitro diagnostic reagents
Suitable instruments: Gene amplification instrument, electrophoresis instrument